Aureobasidin A (AbA) is a cyclic ester peptide antibiotics which derived from filamentous fungi, and it has strong antifungal ability. Aureobasidin A (AbA) inhibits the activity of inositol phosphorylceramide (IPC) synthetase, which is dependent on fungal growth, and interferes with sphingolipid synthesis, thereby further killing the strain.
mSystems. 2022 Oct 20;e0053922.
Systematic Metabolic Profiling Identifies De Novo Sphingolipid Synthesis as Hypha Associated and Essential for Candida albicans Filamentation
Aureobasidin A purchased from AbMole
| Molecular Weight | 1101.43 |
| Formula | C60H92N8O11 |
| CAS Number | 127785-64-2 |
| Solubility (25°C) | Soluble in methanol |
| Storage | 4°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Adriana M Rauseo, et al. Hope on the Horizon: Novel Fungal Treatments in Development
[4] Sabrina Sonda, et al. Inhibitory effect of aureobasidin A on Toxoplasma gondii
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