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ATN-161

Cat. No. M3789
ATN-161 Structure
Size Price Availability Quantity
5mg USD 150 In stock
10mg USD 240 In stock
50mg USD 580 In stock
100mg USD 920 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

ATN-161 is a novel small peptide inhibitor of integrin α5β1; a beta integrin antagonist with antitumor activity. ATN-161 inhibited VEGF-induced migration and capillary tube formation in hCECs. In vivo, injection of ATN-161 after laser photocoagulation inhibited CNV leakage and neovascularization to an extent similar to AF564. Furthermore, SD-OCT and histologic examinations indicated that ATN-161 significantly decreased the size of laser-induced lesions. Treatment with the α5β1 signaling inhibitor ATN-161 significantly blunts atherosclerotic plaque development in apolipoprotein E-deficient mice, characterized by reduced vascular cell adhesion molecule-1 expression and macrophage accumulation without affecting fibrous cap size.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 597.64
Formula C23H35N9O8S
CAS Number 262438-43-7
Purity >99%
Solubility DMSO
Storage at -20°C
References

α5β1 integrin signaling mediates oxidized low-density lipoprotein-induced inflammation and early atherosclerosis.
Yurdagul A Jr, et al. Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1362-73. PMID: 24833794.

The antiangiogenic effects of integrin alpha5beta1 inhibitor (ATN-161) in vitro and in vivo.
Wang W, et al. Invest Ophthalmol Vis Sci. 2011 Sep 14;52(10):7213-20. PMID: 21813636.

Inhibition of integrin alpha5beta1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice.
Stoeltzing O, et al. Int J Cancer. 2003 Apr 20;104(4):496-503. PMID: 12584749.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ATN-161 supplier, Integrin, inhibitors

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