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ATB-346 suppresses gastric prostaglandin E(2) synthesis as effectively as naproxen, but produces negligible damage in the stomach and intestine. ATB-346 accelerates healing of pre-existing gastric ulcers. ATB-346 significantly reduces the severity of inflammation (proinflammatory cytokines, apoptosis of neural tissue, and nitrosative stress) that characterizes the secondary effects of SCI.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 365.45 |
| Formula | C21H19NO3S |
| CAS Number | 1226895-20-0 |
| Purity | >98% |
| Solubility | DMSO |
| Storage | at -20°C |
A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury.
Campolo M, et al. FASEB J. 2013 Nov;27(11):4489-99. PMID: 23901068.
| Related COX Products |
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| Vitamin E
Vitamin E is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. |
| Tenoxicam
Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM. |
| Suprofen
Suprofen is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic. |
| Salicylic acid
Salicylic acid is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity. |
| Propyphenazone
Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors. |
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