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AT2 receptor agonist C21

Cat. No. M13907
AT2 receptor agonist C21 Structure
Size Price Availability Quantity
5mg USD 110  USD110 In stock
10mg USD 180  USD180 In stock
25mg USD 340  USD340 In stock
50mg USD 520  USD520 In stock
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Quality Control & Documentation
Biological Activity

AT2 receptor agonist C21 is a druglike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 µM for the AT2 receptor and AT1 receptor, respectively.

Chemical Information
Molecular Weight 475.62
CAS Number 477775-14-7
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mathias Hallberg, et al. Small-molecule AT2 receptor agonists

[2] Mathias Hallberg, et al. Angiotensin Peptides as AT2 Receptor Agonists

[3] Quaisar Ali, et al. AT2 receptor non-peptide agonist C21 promotes natriuresis in obese Zucker rats

[4] U Muscha Steckelings, et al. Non-peptide AT2-receptor agonists

[5] U Muscha Steckelings, et al. The angiotensin AT2 receptor in left ventricular hypertrophy

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