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Aspirin

Cat. No. M5426
Aspirin Structure
Synonym:

Acetylsalicylic acid

Size Price Availability Quantity
1g USD 50 In stock
5g USD 80 In stock
1g USD 90 In stock
5g USD 150 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 180.16
Formula C9H8O4
CAS Number 50-78-2
Purity >99%
Solubility 36 mg/mL in DMSO
Storage at -20°C
References

Aspirin and lipid mediators in the cardiovascular system.
Schrör K, et al. Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt A):17-23. PMID: 26201059.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Aspirin, Acetylsalicylic acid supplier, COX, inhibitors

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