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Asiatic-acid

Cat. No. M4509
Asiatic-acid Structure
Synonym:

Dammarolic acid, Asiantic acid

Size Price Availability Quantity
20mg USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.

Chemical Information
Molecular Weight 488.70
Formula C30H48O5
CAS Number 464-92-6
Solubility (25°C) 10 mM in DMSO
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zuzanna Sycz, et al. Anti-Planktonic and Anti-Biofilm Properties of Pentacyclic Triterpenes-Asiatic Acid and Ursolic Acid as Promising Antibacterial Future Pharmaceuticals

[2] Guoju Hong, et al. Asiatic Acid Inhibits OVX-Induced Osteoporosis and Osteoclastogenesis Via Regulating RANKL-Mediated NF-κb and Nfatc1 Signaling Pathways

[3] Muhammad T Islam, et al. Anti-Cancer Effects of Asiatic Acid, a Triterpene from Centilla asiatica L: A Review

[4] Ji-Hyun Park, et al. Asiatic acid attenuates methamphetamine-induced neuroinflammation and neurotoxicity through blocking of NF-kB/STAT3/ERK and mitochondria-mediated apoptosis pathway

[5] Wiesława Bylka, et al. Centella asiatica in dermatology: an overview

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Keywords: Asiatic-acid, Dammarolic acid, Asiantic acid supplier, p38 MAPK, inhibitors, activators


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