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Asenapine

Cat. No. M5423
Asenapine Structure
Size Price Availability Quantity
10mg USD 120 In stock
50mg USD 500 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Asenapine(Org 5222) inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 285.77
Formula C17H16ClNO
CAS Number 65576-45-6
Purity >99%
Solubility 10mM in DMSO
Storage at -20°C
References

Asenapine versus placebo for schizophrenia.
Hay A, et al. Cochrane Database Syst Rev. 2015 Nov 24;(11):CD011458. PMID: 26599405.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Asenapine supplier, 5-HT Receptor, inhibitors

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