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Asenapine maleate

Cat. No. M5424
Asenapine maleate Structure
Synonym:

Org 5222

Size Price Availability Quantity
50mg USD 100 In stock
100mg USD 160 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Asenapine maleate is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 401.84
Formula C17H16ClNO.C4H4O4
CAS Number 85650-56-2
Purity >99%
Solubility 80 mg/mL in DMSO
Storage at -20°C
References

Asenapine maleate in situ forming biodegradable implant: an approach to enhance bioavailability.
Avachat AM, et al. Int J Pharm. 2014 Dec 30;477(1-2):64-72. PMID: 25305379.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Asenapine maleate, Org 5222 supplier, 5-HT Receptor, inhibitors

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