Artemisinic acid is an amorphane sesquiterpene isolated from Artemisia annua L., possesses a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity effect.
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Source | J Biosci (2014). Figure 3. Artemisinic-acid |
| Method | NMR analysis | |
| Cell Lines | tobacco chloroplast | |
| Concentrations | 1 mg/ml | |
| Incubation Time | ||
| Results | The overlap of the observed resonances of AA extracted from the transplastomic samples was very similar to the reference AA profile, with only minor differences due to the presence of native plant metabolites |
 |
Source | J Biosci (2014). Figure 2. Artemisinic-acid |
| Method | PCR | |
| Cell Lines | tobacco chloroplast | |
| Concentrations | 500 mg/L | |
| Incubation Time | ||
| Results | Three independent transplastomic shoots surviving on spectinomycin selection medium were tested for PCR and two of them (T1 and T3) were PCR positive as represented by the expected ~2.2 kb amplicon |
| Cell Experiment | |
|---|---|
| Cell lines | C. roseus suspension-cultured cells |
| Preparation method | The solutions of artemisinic acid were prepared in absolute ethanol. Different concentrations of artemisinic acid were added to 12-day-old suspension-cultured cells of C. roseus, and the final concentrations of artemisinic acid were 10, 30 and 50 mg L-1, respectively. |
| Concentrations | 10, 30 and 50 mg/L |
| Incubation time | 24, 48 and 72 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 234.33 |
| Formula | C15H22O2 |
| CAS Number | 80286-58-4 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage | 2-8°C, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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