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APO866

Cat. No. M2287
APO866 Structure
Synonym:

FK866

Size Price Availability Quantity
10mg USD 120 In stock
50mg USD 400 In stock
100mg USD 700 In stock
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Quality Control
Biological Activity

APO866 (FK866) (0.09-27 nM) induces dose-dependent cytotoxicity in 41 hematologic malignant cells including acute myeloid leukemia, acute lymphoblastic leukemia, mantle cell lymphoma, chronic lymphocytic leukemia, and T-cell lymphoma. APO866 (FK866) (0-10 nM) dose-dependently induces depletion of intracellular NAD and ATP contents and cell death in various hematologic cancer cells. APO866 (FK866) (10 nM) inhibits PBEF-induced secretion of MMP-3, CCL2, and CXCL8 in HFFF2 cells. APO866 administered intraperitoneally at dose of 20 mg/kg twice a day for 4 days, repeat weekly over 3 weeks, prevents and abrogats tumor growth in C.B.-17 SCID mice xenograft models of human AML, lymphoblastic lymphoma, and leukemia.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 391.51
Formula C24H29N3O2
CAS Number 658084-64-1
Purity >99%
Solubility Ethanol 50 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: APO866, FK866 supplier, Transferase, inhibitors

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