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Apicidin

Cat. No. M2400

Apicidin  Structure
Size Price Availability
5mg USD 150 Out of stock
10mg USD 250 Out of stock
25mg USD 450 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Apicidin is a potent nonselective HDAC inhibitor with IC50 of 0.7 nM. Apicidin is a fungal metabolite, as well as a histone deacetylase inhibitor. Antiangiogenic and anti-invasive; Apicidin not only blocks proliferation of human stomach and breast cancer cells, but also induces apoptosis and autophagy in human oral squamous carcinoma cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 623.78
Formula C34H49N5O6
CAS Number 183506-66-3
Purity >99%
Solubility DMSO
Storage at -20°C
References

Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin.
Han, et al. Cancer Res. 2000 Nov 1;60(21):6068-74. PMID: 11085529.

Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.
Darkin-Rattray, et al. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7. PMID: 8917558.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Apicidin supplier, HDAC, inhibitors

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