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Anti-human PD-1 mAb

Cat. No. M11385
Anti-human PD-1 mAb Structure
Size Price Availability Quantity
500ug USD 450  USD450 In stock
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Quality Control & Documentation
  • Purity: >95% , Endotoxin <0.01 EU/μg
  • COA
  • MSDS
Biological Activity

Expression host: CHO cells
Purity: >95%. Sds-page gel and HIGH performance liquid chromatography were used
Endotoxin: <0.01 EU/μg
Storage and stability: stored at 2~8℃, valid for 24 months. In case of separate packaging, store in -20℃ storage period of 6 months, -80℃ storage period of 12 months, avoid repeated freeze-thaw.

Biological activity: PD-1 is mainly expressed in activated T cells and B cells, and its function is to inhibit cell activation, which is a normal self-stabilizing mechanism of the immune system. Because excessive T/B cell activation can cause autoimmune diseases, PD-1 is a talisman of our body. However, the tumor microenvironment will induce the infiltrating T cells to overexpress the PD-1 molecule, and the tumor cells will also overexpress the PD-L1 and PD-L2 ligands of PD-1, resulting in the continuous activation of the PD-1 pathway in the tumor microenvironment, resulting in the inhibition of THE FUNCTION of T cells. Antibodies against PD-1 that fail to kill tumor cells can block this pathway, thereby partially restoring the function of T cells and enabling T cells to continue to kill tumor cells. Therefore, anti-HUMAN PD-1 monoclonal antibody was used to "block" the amplified T cells in vitro, thus significantly improving the killing effect of immune cells on the tumor in patients.

Chemical Information
Solubility (25°C) N/A
Storage 2-8℃
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] L Marotte, et al. Oncoimmunology. Anti-tumor efficacy of a combination therapy with PD-L1 targeted alpha therapy and adoptive cell transfer of PD-1 deficient melanoma-specific human T-lymphocytes

[2] Marisa Capitao, et al. Cancers (Basel). Anti-Tumor Efficacy of PD-L1 Targeted Alpha-Particle Therapy in a Human Melanoma Xenograft Model

[3] Ziwei Li, et al. Onco Targets Ther. The Immunostimulative Effect and Mechanisms of a Novel Mouse Anti-Human PD-1 Monoclonal Antibody on Jurkat Lymphocytic Cells Cocultured with Hepatoma Cells

[4] Ziwei Li, et al. Int J Oncol. Expression and clinical significance of PD‑1 in hepatocellular carcinoma tissues detected by a novel mouse anti-human PD‑1 monoclonal antibody

[5] Sarah L Buchan, et al. Clin Cancer Res. PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8 + T-Cell-Driven Antitumor Immunity

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