Expression host: CHO cells
Endotoxin: <2EU/mg
Purity: > 98%
Concentration: 1 mg/mL
Storage and stability: stored at -20℃ for 6 months after opening, stored at -80℃ for 12 months. Avoid repeated freezing and thawing
Biological activity: HER2, also known as ErbB2, is a member of the human epidermal growth factor receptor family and plays an important role in signal transduction. Her-2/ NEU protein mediated signal transduction pathway mainly includes Ras/Raf/ mitin-activated protein kinase (MAPK) pathway and phosphatidylinositol pathway. 3 hydroxyl kinase (P13K)/Akt pathway, signal transduction and transcriptional activation (STAT) pathway and PLC pathway. 2 Expression of HER-2 / NEu protein in gastric cancer and its influencing factors Her-2/ NEu protein is usually only expressed in fetal period, and is only expressed at low level in very few tissues after adulthood.
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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