Expression host: CHO cells
Purity: > 95 %. Sds-page and HIGH performance liquid chromatography were used for analysis
Endotoxin: < 0.01EU/μg
Biological activity: CD20 is a specific marker molecule on the surface of B lymphocytes. It is expressed on more than 95% of normal or malignant B lymphocytes and is not expressed in hematopoietic stem cells, progenitor cells, and other normal tissues. It is composed of 297 amino acids and has a molecular weight of 33kD. It belongs to non-glycosylated phosphoprotein from 34 to 36kD. Its antigenic epitope is a ring region composed of 43 amino acids in the third and fourth transmembrane regions. CD20 is an ideal antigen for the treatment of B-lymphocyt-related diseases because it has no obvious internalization and no obvious cell surface shedding after binding with antibody. Since the original normal B cells were not affected by the anti-CD20 monoclonal antibody, the anti-CD20 monoclonal antibody was able to rebuild the B cell population after killing most, if not all, lymphoma cells expressing the CD20 molecule as well as normal B cells. Therefore, anti-CD20 monoclonal antibodies are increasingly used in the treatment of B-cell related diseases.
| Storage | Stored at ≤ -20°C, stable for one year after receipt. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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