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Anti-human CD16 mAb

Cat. No. M11383
Anti-human CD16 mAb Structure
Size Price Availability Quantity
500ug USD 450  USD450 In stock
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Quality Control & Documentation
  • Purity: >95% , Endotoxin < 0.01 EU/μg
  • COA
  • MSDS
Biological Activity

Expression host: CHO cells
Purity: > 95%. Sds-page gel and HIGH performance liquid chromatography were used
Endotoxin: < 0.01 EU/μg
Storage and stability: stored at 2~8℃, valid for 24 months. In case of separate packaging, store in -20℃ storage period of 6 months, -80℃ storage period of 12 months, avoid repeated freeze-thaw.

Bioactivity: CD16 is FcγR ⅲ, a glycoprotein with a molecular weight of 50-70kD, a member of Ig superfamily, known to be involved in antigen-dependent cytotoxicity (ADCC). The most significant feature of CD16 is that the cleavage triggered by membrane receptors is performed by NK cells. CD16 acts as a low affinity receptor for the Fc portion of some IgG, binding to the Fcε -associated receptor I (εRI of Fc) γ chain of CD3ζ and co-participates in signal transduction. NK cell CD16 directly leads to an increase in intracellular Ca+ levels and a cascade of biochemical reactions similar to T cell receptor activation.

Chemical Information
Solubility (25°C) N/A
Storage 2-8℃
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rym Ben Abdelwahed, et al. Invest Ophthalmol Vis Sci. Preclinical study of Ublituximab, a Glycoengineered anti-human CD20 antibody, in murine models of primary cerebral and intraocular B-cell lymphomas

[2] Domenico Mavilio, et al. Blood. Identification of NKG2A and NKp80 as specific natural killer cell markers in rhesus and pigtailed monkeys

[3] G Mota, et al. Scand J Immunol. Interaction of human immunoglobulin G with CD16 on natural killer cells: ligand clearance, FcgammaRIIIA turnover and effects of metalloproteinases on FcgammaRIIIA-mediated binding, signal transduction and killing

[4] F Vely, et al. Hybridoma. A new set of monoclonal antibodies against human Fc gamma RII (CD32) and Fc gamma RIII (CD16): characterization and use in various assays

[5] Y W Huang, et al. Stem Cells. Immunotherapy of multiple myeloma

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