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Anlotinib

Cat. No. M6181
Anlotinib Structure
Size Price Availability Quantity
5mg USD 450 In stock
10mg USD 650 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Anlotinib is a EGFR inhibitor extracted from patent 2015185012 A1, compound 1,which can be used to treat non-small cell lung cancer.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 407.44
Formula C23H22FN3O3
CAS Number 1058156-90-3
Purity >98%
Solubility 44 mg/mL in DMSO
Storage at -20°C
References

The Safety and Efficacy of the S1/Temozolomide Regimen in Patients with Metastatic Neuroendocrine Tumors.
Zhao J, et al. Neuroendocrinology. 2017 Aug 17. PMID: 28817826.

Safety, pharmacokinetics, and antitumor properties of anlotinib, an oral multi-target tyrosine kinase inhibitor, in patients with advanced refractory solid tumors.
Sun Y, et al. J Hematol Oncol. 2016 Oct 4;9(1):105. PMID: 27716285.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Anlotinib supplier, EGFR/HER2, inhibitors

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