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Angiotensin-(1-7)

Cat. No. M9079
Angiotensin-(1-7) Structure
Synonym:

TXA127; Ang-(1-7)

Size Price Availability Quantity
10mg USD 100 In stock
25mg USD 225 In stock
50mg USD 360 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Angiotensin (1-7) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7), inhibits purified canine angiotensin converting enzyme (ACE) activity with an IC50 of 0.65 μM. At a concentration of 2 μM Angiotensin (1-7), relaxation to BK is increased 92% compared to BK alone (41±4.4% versus 92±2.5%, P<0.01). Angiotensin (1-7) possesses novel biological functions that are distinct from Ang II.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 899.0
Formula C41H62N12O11
CAS Number 51833-78-4
Purity >98%
Solubility Water: ≥ 20 mg/mL
Storage at -20°C
References

Role of Mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated rats.
Saberi S, et al. Res Pharm Sci. 2016 Jan-Feb;11(1):65-72. PMID: 27051434.

Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis.
Khajah MA, et al. PLoS One. 2016 Mar 10;11(3):e0150861. PMID: 26963721.

Angiotensin-(1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2.
Alzayadneh EM, et al. Cell Signal. 2014 Dec;26(12):3027-35. PMID: 25246357.

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Keywords: Angiotensin-(1-7), TXA127; Ang-(1-7) supplier, Angiotensin Receptor, inhibitors

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