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Angiotensin-(1-7)

Cat. No. M9079
Angiotensin-(1-7) Structure
Synonym:

TXA127; Ang-(1-7)

Size Price Availability Quantity
10mg USD 80  USD80 In stock
25mg USD 160  USD160 In stock
50mg USD 260  USD260 In stock
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Quality Control & Documentation
Biological Activity

Angiotensin (1-7) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7), inhibits purified canine angiotensin converting enzyme (ACE) activity with an IC50 of 0.65 μM. At a concentration of 2 μM Angiotensin (1-7), relaxation to BK is increased 92% compared to BK alone (41±4.4% versus 92±2.5%, P<0.01). Angiotensin (1-7) possesses novel biological functions that are distinct from Ang II.

Chemical Information
Molecular Weight 899.0
Formula C41H62N12O11
CAS Number 51833-78-4
Solubility (25°C) Water: ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Saberi S, et al. Res Pharm Sci. Role of Mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated rats.

[2] Khajah MA, et al. PLoS One. Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis.

[3] Alzayadneh EM, et al. Cell Signal. Angiotensin-(1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2.

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Keywords: Angiotensin-(1-7), TXA127; Ang-(1-7) supplier, Angiotensin Receptor, inhibitors, activators


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