Angiotensin (1-7) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7), inhibits purified canine angiotensin converting enzyme (ACE) activity with an IC50 of 0.65 μM. At a concentration of 2 μM Angiotensin (1-7), relaxation to BK is increased 92% compared to BK alone (41±4.4% versus 92±2.5%, P<0.01). Angiotensin (1-7) possesses novel biological functions that are distinct from Ang II.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Water: ≥ 20 mg/mL|
Role of Mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated rats.
Saberi S, et al. Res Pharm Sci. 2016 Jan-Feb;11(1):65-72. PMID: 27051434.
Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis.
Khajah MA, et al. PLoS One. 2016 Mar 10;11(3):e0150861. PMID: 26963721.
Angiotensin-(1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2.
Alzayadneh EM, et al. Cell Signal. 2014 Dec;26(12):3027-35. PMID: 25246357.
|Related Angiotensin Receptor Products|
A-779 is a specific antagonist of G-protein coupled receptor (Mas receptor).
Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
EMA401 (also known as Olodanrigan and PD-126055) is a highly selective angiotensin AT2 antagonist.
|Angiotensin II human
Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity.
Tranilast is an antiallergic agent.
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