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AN15368

Cat. No. M21534
AN15368 Structure
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Biological Activity

AN15368 is an oral cleavage and polyadenylate specific factor (CPSF3) inhibitor being developed for use in Chagas disease (also known as American trypanosomiasis).

Chemical Information
Molecular Weight 389.25
Formula C20H28BNO6
CAS Number 2152662-92-3
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rick L Tarleton. Trends Parasitol. Effective drug discovery in Chagas disease

[2] Angel M Padilla, et al. Nat Microbiol. Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates

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  Catalog
Abmole Inhibitor Catalog




Keywords: AN15368 supplier, inhibitors, activators


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