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Amyloid beta-peptide(25-35)

Cat. No. M9071
Amyloid beta-peptide(25-35) Structure
Synonym:

Aβ25-35; β-Amyloid peptide(25-35)

Size Price Availability Quantity
5mg USD 280 In stock
10mg USD 430 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells. Amyloid beta-peptide(25-35) is also investigated in gel state for the first time. Comparative studies are also carried out using vibrational absorption and ECD. Amyloid beta-peptide(25-35) induces apoptotic effects on isolated brain mitochondria and the redox state of methionine-35.

In vivo, rats injected with Aβ25–35 peptide intracerebroventricularly and compound Danshen (CDS) are subsequently administered once daily for 23 days. The Alzheimer' s disease (AD) model group present with spatial learning and memory impairments. CDS and donepezil administration significantly ameliorate the Aβ25–35 peptide-induced memory impairment in both Morris water maze (P < 0.05) and passive avoidance task (P < 0.01) compared to the AD model group.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1060.27
Formula C45H81N13O14S
CAS Number 131602-53-4
Purity >98%
Solubility DMSO: ≥ 60 mg/mL
Storage at -20°C
References

Cognitive improvement of compound danshen in an Aβ25-35 peptide-induced rat model of Alzheimer's disease.
Liu M, et al. BMC Complement Altern Med. 2015 Oct 23;15:382. PMID: 26497584.

Abeta(31-35) and Abeta(25-35) fragments of amyloid beta-protein induce cellular death through apoptotic signals: Role of the redox state of methionine-35.
Clementi ME, et al. FEBS Lett. 2005 May 23;579(13):2913-8. PMID: 15890345.

Solution structure of amyloid beta-peptide (25-35) in different media.
DUrsi AM, et al. J Med Chem. 2004 Aug 12;47(17):4231-8. PMID: 15293994.

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Keywords: Amyloid beta-peptide(25-35), Aβ25-35; β-Amyloid peptide(25-35) supplier, inhibitors

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