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Amoxicillin trihydrate

Cat. No. M19906
Amoxicillin trihydrate Structure
Synonym:

Amoxil trihydrate; Amoxipen trihydrate; Moxaline trihydrate

Size Price Availability Quantity
500mg USD 47  USD47 In stock
1g USD 56  USD56 In stock
5g USD 90  USD90 In stock
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Biological Activity

Amoxicillin is a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity.

Chemical Information
Molecular Weight 419.45
Formula C16H25N3O8S
CAS Number 61336-70-7
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Emine Bulut, et al. Int J Biol Macromol. Synthesis and characterization of temperature-sensitive microspheres based on acrylamide grafted hydroxypropyl cellulose and chitosan for the controlled release of amoxicillin trihydrate

[2] Saranya Poapolathep, et al. J Vet Pharmacol Ther. Pharmacokinetic profiles of amoxicillin trihydrate in freshwater crocodiles (Crocodylus siamensis) after intramuscular administration at two doses

[3] A Huttner, et al. Clin Microbiol Infect. Oral amoxicillin and amoxicillin-clavulanic acid: properties, indications and usage

[4] Bo-Hao Tang, et al. Antimicrob Agents Chemother. Population Pharmacokinetics and Dosing Optimization of Amoxicillin in Neonates and Young Infants

[5] Dhanusha Thambavita, et al. J Pharm Sci. Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Amoxicillin Trihydrate

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Keywords: Amoxicillin trihydrate, Amoxil trihydrate; Amoxipen trihydrate; Moxaline trihydrate supplier, Antibiotic, inhibitors, activators

 
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