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Amodiaquin dihydrochloride dihydrate

Cat. No. M5412
Amodiaquin dihydrochloride dihydrate Structure
Synonym:

Amodiaquine dihydrochloride dihydrate

Size Price Availability Quantity
100mg USD 60 In stock
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Quality Control
Biological Activity

Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase in human erythrocytes, also used as an antimalarial and anti-inflammatory agent.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 464.81
Formula C20H22ClN3O.2HCl.2H2O
CAS Number 6398-98-7
Purity 100.00%
Solubility 90 mg/mL in DMSO
Storage at -20°C
References

Solid-State Characterization and Interconversion of Recrystallized Amodiaquine Dihydrochloride in Aliphatic Monohydric Alcohols.
Sirikun W, et al. AAPS PharmSciTech. 2016 Apr;17(2):427-35. PMID: 26206402.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Amodiaquin dihydrochloride dihydrate, Amodiaquine dihydrochloride dihydrate supplier, Histone Methyltransferase, inhibitors

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