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Ammonium iron(III) citrate

Cat. No. M13544
Ammonium iron(III) citrate Structure
Synonym:

Ammonium ferric citrate; FAC

Size Price Availability Quantity
5mg USD 50  USD50 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis. Ammonium iron(III) citrate can enhance protein production.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number 1185-57-5
Purity >99%
Solubility Water 33.33 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Fang Wang, et al. Food Chem Toxicol. Ferric ammonium citrate (FAC)-induced inhibition of osteoblast proliferation/differentiation and its reversal by soybean-derived peptides (SDP)

[2] Wei Wu, et al. Int J Med Sci. Ammonium Ferric Citrate induced Ferroptosis in Non-Small-Cell Lung Carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity

[3] Xiaoyan Zeng, et al. Neurochem Res. Benefits of Iron Chelators in the Treatment of Parkinson's Disease

[4] Yongting Qiu, et al. Environ Technol. Effect of complex iron on the phosphorus absorption by two freshwater algae

[5] Yue Hu, et al. Spectrochim Acta A Mol Biomol Spectrosc. Fluorometric assay of iron(II) lactate hydrate and ammonium ferric citrate in food and medicine based on poly(sodium-p-styrenesulfonate)-enhanced Ag nanoclusters

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Keywords: Ammonium iron(III) citrate, Ammonium ferric citrate; FAC supplier, Ferroptosis, inhibitors

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