Mono-ammonium glycyrrhizinate (AMGZ) is a unique product derived from Licorice root and has an extremely sweet taste. It is an excellent foaming agent that acts as a co-emulsifier. It is also excellent in recipes that require gelling or suspension properties for a consistent feeling in the mouth or a stable cloud effect in the product.Very small quantities are required to achieve the desired results, usually a few parts per million. However, varying amounts should be evaluated in your product for best taste.MAGZ is up to 50 times sweeter than sucrose — and can greatly enhance an already sweetened product as a result of synergies with both natural and synthetic sweeteners. It was found to be active against viruses, while not affecting cell activity and ability to replicate. It was also reported that glycyrrhizic acid inactivates herpes simplex particles irreversibly.
| Molecular Weight | 839.96 |
| Formula | C42H62O16.NH3 |
| CAS Number | 1407-03-0 |
| Solubility (25°C) | DMSO 100 mg/mL Water 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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