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Amlodipine Besylate

Cat. No. M5411

Amlodipine Besylate Structure
Size Price Availability Quantity
100mg USD 70 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 567.05
Formula C20H25ClN2O5.C6H6O3S
CAS Number 111470-99-6
Purity >99%
Solubility 113 mg/mL in DMSO
Storage at -20°C
References

Combined treatment with olmesartan medoxomil and amlodipine besylate attenuates atherosclerotic lesion progression in a model of advanced atherosclerosis.
Sievers P, et al. Drug Des Devel Ther. 2015 Jul 29;9:3935-42. PMID: 26251572.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Amlodipine Besylate supplier, Calcium Channel, inhibitors

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