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Aminoadipic acid

Cat. No. M9848
Aminoadipic acid Structure
Synonym:

2-aminoadipic acid

Size Price Availability Quantity
500mg USD 52  USD52 In stock
1g USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

2-Aminoadipic acid is a six-carbon homolog of glutamate and a gliotoxic compound. It is generally used to considerably reduce the number of astroglia in cerebellar cultures that acts as a model to study the mechanisms of a-aminoadipic acid induced glial toxicity.

Chemical Information
Molecular Weight 161.16
Formula C6H11NO4
CAS Number 542-32-5
Form Solid
Solubility (25°C) Water 3 mg/mL
1 M HCl (35 mg/ml)
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yunna Kim, et al. J Ginseng Res . Antidepressant effects of ginsenoside Rf on behavioral change in the glial degeneration model of depression by reversing glial loss

[2] Hongqiao Lin, et al. Free Radic Biol Med. Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo

[3] Xiaolei Wang, et al. Dvrg Des Devel Ther. α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension

[4] Thomas J Wang, et al. J Clin Invest. 2-Aminoadipic acid is a biomarker for diabetes risk

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