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Amarogentin

Cat. No. M9348
Amarogentin Structure
Size Price Availability Quantity
5mg USD 90 In stock
10mg USD 150 In stock
25mg USD 300 In stock
50mg USD 547 In stock
100mg USD 995 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 586.54
Formula C29H30O13
CAS Number 21018-84-8
Purity >98%
Solubility Methanol ≥ 30 mg/mL
Storage 2-8°C, dry, sealed
References

Protective Effects of Amarogentin against Carbon Tetrachloride-Induced Liver Fibrosis in Mice.
Zhang Y, et al. Molecules. 2017 May 6;22(5). PMID: 28481234.

Amarogentin Displays Immunomodulatory Effects in Human Mast Cells and Keratinocytes.
Wolfle U, et al. Mediators Inflamm. 2015;2015:630128. PMID: 26600671.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Amarogentin supplier, inhibitors

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