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Alvimopan dihydrate

Cat. No. M5403
Alvimopan dihydrate Structure
Size Price Availability Quantity
5mg USD 140 In stock
10mg USD 230 In stock
50mg USD 670 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Alvimopan dihydrate(LY 246736; ADL 8-2698) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 460.56
Formula C25H36N2O6
CAS Number 170098-38-1
Purity >99%
Solubility 10mM in DMSO
Storage at -20°C
References

Economic Impact of Alvimopan Considering Varying Definitions of Postoperative Ileus.
Earnshaw SR, et al. J Am Coll Surg. 2015 Nov;221(5):941-50. PMID: 26353904.

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  Catalog
Abmole Inhibitor Catalog 2017




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