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Alvelestat (AZD9668)

Cat. No. M5402
Alvelestat (AZD9668) Structure
Synonym:

AZD9668

Size Price Availability Quantity
5mg USD 120  USD120 In stock
10mg USD 210  USD210 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Alvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. 

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 545.53
Formula C25H22F3N5O4S
CAS Number 848141-11-7
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Yamada K, et al. Mol Genet Metab. Elevation of pivaloylcarnitine by sivelestat sodium in two children.

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