Aluminum Hydroxide is an orally active main form of aluminum used as adjuvant. Aluminum Hydroxide also acts as adjuvant to compensate low inherent immunogenicity of subunit vaccines. In vivo, Aluminum Hydroxide (100 mg/kg/day; orally; 7 days) increases lipid peroxidation and decreases the activity of SOD in the brain. Aluminum hydroxide is insoluble in water but soluble in acid or alkali.
| Molecular Weight | 78 |
| Formula | AlH3O3 |
| CAS Number | 21645-51-2 |
| Solubility (25°C) | Soluble in acid or alkali |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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| Heparin sodium salt (MW 15kDa)
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