Alternariol is a mycotoxin produced by Alternaria species. Alternariol inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes.
Molecular Weight | 258.23 |
Formula | C14H10O5 |
CAS Number | 641-38-3 |
Storage | 2-8°C, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] S Marin, et al. Food Chem Toxicol. Mycotoxins: occurrence, toxicology, and exposure assessment
[3] Sreekanth Dasari, et al. Acta Crystallogr Sect E Struct Rep Online. Alternariol 9-O-methyl ether
[4] David Siegel, et al. Acta Crystallogr Sect E Struct Rep Online. Alternariol
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