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Altenuene

Cat. No. M11534
Altenuene Structure
Size Price Availability Quantity
1mg USD 195  USD195 In stock
5mg USD 550  USD550 In stock
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Quality Control & Documentation
Biological Activity

Altenuene belongs to plant extraction compounds, hydrophilic plant extracts can choose water, methanol, ethanol as solvents, lipophilic plant extracts please choose petroleum ether, benzene and other organic solvents.

Chemical Information
Molecular Weight 292.28
Formula C15H16O6
CAS Number 29752-43-0
Solubility (25°C) DMSO 90 mg/mL
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Michael A Sebald, et al. Molecules. First Synthesis of (-)-Altenuene-D 3 Suitable as Internal Standard for Isotope Dilution Mass Spectrometry

[2] J Bhagat, et al. J Appl Microbiol. Cholinesterase inhibitor (Altenuene) from an endophytic fungus Alternaria alternata: optimization, purification and characterization

[3] David Siegel, et al. J Agric Food Chem. Degradation of the Alternaria mycotoxins alternariol, alternariol monomethyl ether, and altenuene upon bread baking

[4] Erika Pfeiffer, et al. Mol Nutr Food Res. Oxidative in vitro metabolism of the Alternaria toxins altenuene and isoaltenuene

[5] Ping Jiao, et al. J Nat Prod. Altenuene derivatives from an unidentified freshwater fungus in the family Tubeufiaceae

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