Free shipping on all orders over $ 500

α-cyano-4-hydroxy-cinnamic acid

Cat. No. M9202
α-cyano-4-hydroxy-cinnamic acid Structure


Size Price Availability Quantity
100mg USD 77 In stock
200mg USD 97 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

α-CHCA is a classic monocarboxylate transporters (MCT) inhibitor. In the sensitive U251 cells, CHCA is able to inhibit cell proliferation and induce cell death, having a cytotoxic effect; however, in the less sensitive SW1088 cells, CHCA only inhibits cell proliferation but did not induce cell death. Transport by MCT1, 2, and 4 is competitively inhibited by CHCA whereas transport by MCT3 is insensitive to α-cyano-4-hydroxy-cinnamic acid.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 189.17
Formula C10H7NO3
CAS Number 28166-41-8
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C

Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets.
Miranda-Goncalves V, et al. Neuro Oncol. 2013 Feb;15(2):172-88. PMID: 23258846.

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
Sonveaux P, et al. J Clin Invest. 2008 Dec;118(12):3930-42. PMID: 19033663.

Related Products

JNJ-47117096 is potent and selective MELK inhibitor with IC50 of 23 nM.

Sodium iodoacetate


Phytohemagglutinin is a lectin obtained from the red kidney bean that binds to the membranes of T-cells, stimulates metabolic activity and involves inflammatory pathways.


Apilimod is a potent IL-12/IL-23 inhibitor, and it is also a cell permeable small molecule which specifically inhibits PIKfyve with an IC50 of 14 nM in an in vitro kinase assay.

10-Hydroxy-trans-2-decenoic acid

10-Hydroxy-trans-2-decenoic acid is the principal lipid component in royal jelly which is the food for queen and larvae honeybees.

Abmole Inhibitor Catalog 2017

Keywords: α-cyano-4-hydroxy-cinnamic acid, ACCA; α-CHCA supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.