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α-cyano-4-hydroxy-cinnamic acid

Cat. No. M9202
α-cyano-4-hydroxy-cinnamic acid Structure
Synonym:

ACCA; α-CHCA

Size Price Availability Quantity
100mg USD 77 In stock
200mg USD 97 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

α-CHCA is a classic monocarboxylate transporters (MCT) inhibitor. In the sensitive U251 cells, CHCA is able to inhibit cell proliferation and induce cell death, having a cytotoxic effect; however, in the less sensitive SW1088 cells, CHCA only inhibits cell proliferation but did not induce cell death. Transport by MCT1, 2, and 4 is competitively inhibited by CHCA whereas transport by MCT3 is insensitive to α-cyano-4-hydroxy-cinnamic acid.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 189.17
Formula C10H7NO3
CAS Number 28166-41-8
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
References

Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets.
Miranda-Goncalves V, et al. Neuro Oncol. 2013 Feb;15(2):172-88. PMID: 23258846.

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
Sonveaux P, et al. J Clin Invest. 2008 Dec;118(12):3930-42. PMID: 19033663.

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Keywords: α-cyano-4-hydroxy-cinnamic acid, ACCA; α-CHCA supplier, inhibitors

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