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Alloepipregnanolone

Cat. No. M19973
Alloepipregnanolone  Structure
Size Price Availability Quantity
100mg USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Alloepipregnanolone is a progesterone with hypnotic and sedative effects that interferes with the rapid tolerance to the anti-anxiety effects of ethanol.

Chemical Information
Molecular Weight 318.49
Formula C21H34O2
CAS Number 516-55-2
Solubility (25°C) DMSO 3 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Claire-Marie Vacher, et al. Nat Neurosci. Placental endocrine function shapes cerebellar development and social behavior

[2] Julia Bukanova, et al. Biomolecules. Epipregnanolone as a Positive Modulator of GABAA Receptor in Rat Cerebellar and Hippocampus Neurons

[3] Shiyi Chen, et al. Pharmacol Res. Allopregnanolone in mood disorders: Mechanism and therapeutic development

[4] Nicola Pluchino, et al. Horm Mol Biol Clin Investig. Brain intracrinology of allopregnanolone during pregnancy and hormonal contraception

[5] Katherine McEvoy, et al. Int Rev Psychiatry. Allopregnanolone and reproductive psychiatry: an overview

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