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Alliin

Cat. No. M19456
Alliin Structure
Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 135  USD135 In stock
20mg USD 225  USD225 In stock
50mg USD 425  USD425 In stock
100mg USD 680  USD680 In stock
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Quality Control & Documentation
Biological Activity

(±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (Mpro).

Chemical Information
Molecular Weight 177.22
Formula C6H11NO3S
CAS Number 17795-26-5
Form Solid
Solubility (25°C) Water 125 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hilal Ozturk, et al. Biomed Phys Eng Express. In silico investigation of Alliin as potential activator for AMPA receptor

[2] Ni Li, et al. Exp Ther Med. Alliin inhibits adipocyte differentiation by downregulating Akt expression: Implications for metabolic disease

[3] Gaber El-Saber Batiha, et al. Nutrients. Chemical Constituents and Pharmacological Activities of Garlic ( Allium sativum L.): A Review

[4] Rui Zhao, et al. Biochem Biophys Res Commun. Alliin alleviates myocardial ischemia-reperfusion injury by promoting autophagy

[5] Michał Majewski. Rocz Panstw Zakl Hig. Allium sativum: facts and myths regarding human health

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