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all-trans 4-Keto Retinoic Acid

Cat. No. M9219
all-trans 4-Keto Retinoic Acid Structure
Synonym:

all-trans-4-Oxoretinoic acid

Size Price Availability Quantity
2mg USD 150 In stock
5mg USD 250 In stock
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Biological Activity

all-trans 4-Keto Retinoic Acid is an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 314.42
Formula C20H26O3
CAS Number 38030-57-8
Purity 98.74%
Solubility Water
Storage at -20°C
References

4-oxo-retinoic acid is generated from its precursor canthaxanthin and enhances gap junctional communication in 10T1/2 cells.
Stahl W, et al. Adv Exp Med Biol. 1996;387:121-8. PMID: 8794203.

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Keywords: all-trans 4-Keto Retinoic Acid, all-trans-4-Oxoretinoic acid supplier, inhibitors

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