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Aliskiren Hemifumarate

Cat. No. M5398
Aliskiren Hemifumarate Structure
Synonym:

CGP 60536; CGP60536B; SPP 100

Size Price Availability Quantity
10mg USD 60  USD60 In stock
50mg USD 125  USD125 In stock
100mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.

Chemical Information
Molecular Weight 609.83
Formula C30H53N3O6.1/2C4H4O4
CAS Number 173334-58-2
Form Solid
Solubility (25°C) 100 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ebeid WM, et al. J Chromatogr Sci. Simultaneous Determination of Aliskiren Hemifumarate, Amlodipine Besylate and Hydrochlorothiazide in Spiked Human Plasma Using UPLC-MS/MS.

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Keywords: Aliskiren Hemifumarate, CGP 60536; CGP60536B; SPP 100 supplier, Renin, inhibitors, activators


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