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Alfuzosin HCl

Cat. No. M5396
Alfuzosin HCl Structure
Synonym:

SL 77499-10

Size Price Availability Quantity
10mg USD 50 In stock
50mg USD 160 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 425.91
Formula C19H27N5O4.HCl
CAS Number 81403-68-1
Purity >98%
Solubility 85 mg/mL in DMSO
Storage at -20°C
References

Spectrophotometric Determination of Alfuzosin HCl in Pharmaceutical Formulations with some Sulphonephthalein Dyes.
Ashour S, et al. Int J Biomed Sci. 2006 Sep;2(3):273-8. PMID: 23674990.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Alfuzosin HCl, SL 77499-10 supplier, Androgen Receptor, inhibitors

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