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Alcaftadine

Cat. No. M5393
Alcaftadine Structure
Synonym:

Lastacaft, R89674, R 89674, R-89674

Size Price Availability Quantity
10mg USD 60 In stock
50mg USD 200 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Alcaftadine is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. Alcaftadine is also an antagonist for H2 and H4 receptors with no affinity for the H3 receptor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 307.39
Formula C19H21N3O
CAS Number 147084-10-4
Purity >99%
Solubility 28 mg/mL in DMSO
Storage at -20°C
References

Update and clinical utility of alcaftadine ophthalmic solution 0.25% in the treatment of allergic conjunctivitis.
Chigbu DI, et al. Clin Ophthalmol. 2015 Jul 8;9:1215-25. PMID: 26185412.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Alcaftadine, Lastacaft, R89674, R 89674, R-89674 supplier, Histamine Receptor, inhibitors

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