Free shipping on all orders over $ 500

Alcaftadine

Cat. No. M5393
Alcaftadine Structure
Synonym:

Lastacaft, R89674, R 89674, R-89674

Size Price Availability Quantity
10mg USD 60  USD60 In stock
50mg USD 180  USD180 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Alcaftadine is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. Alcaftadine is also an antagonist for H2 and H4 receptors with no affinity for the H3 receptor.

Chemical Information
Molecular Weight 307.39
Formula C19H21N3O
CAS Number 147084-10-4
Solubility (25°C) 28 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chigbu DI, et al. Clin Ophthalmol. Update and clinical utility of alcaftadine ophthalmic solution 0.25% in the treatment of allergic conjunctivitis.

Related Histamine Receptor Products
Peptide 401

Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

Granuliberin R

Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa.

Dimethindene maleate

Dimethindene maleate is a selective histamine H1 receptor antagonist with antihistamine activity.Dimethindene maleate may be used in studies related to allergic reactions.

4-Methylhistamine

4-Methylhistamine is a potent agonist of histamine 4 receptor (H4R).

H4R antagonist 3

H4R antagonist 3 is a histamine-4 receptor antagonist with an EC50 of <10 mM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Alcaftadine, Lastacaft, R89674, R 89674, R-89674 supplier, Histamine Receptor, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.