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AKP-11

Cat. No. M6125
AKP-11 Structure
Size Price Availability Quantity
5mg USD 195 In stock
10mg USD 320 In stock
50mg USD 1050 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

AKP-11 treatment caused milder and reversible lymphopenia as compared to the severe and long lasting lymphopenia observed with FTY720. Secondly, AKP-11 treatment did not cause adverse effects observed with FTY720 treatment. These findings indicate that AKP-11 mediated S1P1 agonist activity may be of therapeutic value for MS and other immune mediated disorders with better safety profile.

Protocol
Cell Experiment
Cell lines CHO cells
Preparation method Before treatment with AKP-11 or FTY720 or FTY720P (Echelon Biosciences Inc. Salt Lake City, UT), the cells were serum starved in six well plates for 4hrs at 37°C and then they were incubated with the above compounds at 37°C.
Concentrations 400μg/ml
Incubation time 1h
Animal Experiment
Animal models Rats
Formulation
Dosages 1.3mg/kg
Administration oral
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 443.88
Formula C22H22ClN3O5
CAS Number 1220973-37-4
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis.
Samuvel DJ, et al. PLoS One. 2015 Oct 29;10(10):e0141781. PMID: 26513477.

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  Catalog
Abmole Inhibitor Catalog 2017




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