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Ajmaline

Cat. No. M20920
Ajmaline Structure
Synonym:

Ajmalan-17

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Biological Activity

Ajmaline is an alkaloid that is class Ia antiarrhythmic agent.

Chemical Information
Molecular Weight 326.43
Formula C20H26N2O2
CAS Number 4360-12-7
Solubility (25°C) DMSO 65 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alessandro Rizzo, et al. Am J Cardiol. Ajmaline Testing and the Brugada Syndrome

[2] Ozcan Ozeke, et al. Int J Cardiol. Ajmaline-induced Epsilon wave: Its role is not only for diagnosis but also for risk stratification

[3] S M Said, et al. Dtsch Med Wochenschr. [Ajmaline test]

[4] M Lounasmaa, et al. Alkaloids Chem Biol. The ajmaline group of indole alkaloids

[5] M Ilyas. J Pak Med Assoc. Ajmaline in the management of cardiac arrhythmias

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