AGN194204 (IRX4204) is inactive against RAR and is an orally active and selective RXR agonist with Kd values of 0.4 nM, 3.6 nM and 3.8 nM for RXRα, RXRβ and RXRγ, respectively, and EC50s of 0.2 nM, 0.8 nM and 0.08 nM. AGN194204 has anti-inflammatory and anti-cancer effects.
Molecular Weight | 352.51 |
Formula | C24H32O2 |
CAS Number | 220619-73-8 |
Solubility (25°C) | N/A |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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