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AdipoRon hydrochloride

Cat. No. M6407
AdipoRon hydrochloride Structure
Size Price Availability Quantity
5mg USD 180  USD180 In stock
10mg USD 300  USD300 In stock
25mg USD 580  USD580 In stock
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Quality Control & Documentation
Biological Activity

AdipoRon hydrochloride is a agonist of adiponectin receptors AdipoR1 and AdipoR2 (Kd values are 1.8 and 3.1 μM respectively). Activates AMPK and PPARα signaling; ameliorates insulin resistance, dyslipidemia and glucose intolerance in db/db mice. Orally active antidiabetic agent.

Chemical Information
Molecular Weight 464.98
Formula C27H28N2O3.HCl
CAS Number 1781835-20-8
Solubility (25°C) DMSO 46.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hansen, et al. Eur J Endocrinol. Pharmacological characterisation of a new oral GH secretagogue, NN703.

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