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Adiphenine

Cat. No. M5389
Adiphenine  Structure
Size Price Availability Quantity
100mg USD 70 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 347.88
Formula C20H25NO2.HCl
CAS Number 50-42-0
Purity >99%
Solubility 70 mg/mL in water
Storage at -20°C
References

The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms.
Spitzmaul G, et al. Br J Pharmacol. 2009 Jul;157(5):804-17. PMID: 19422391.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Adiphenine supplier, AChE, inhibitors

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