Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||70 mg/mL in water|
The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms.
Spitzmaul G, et al. Br J Pharmacol. 2009 Jul;157(5):804-17. PMID: 19422391.
|Related AChE Products|
Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.
Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.
Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction.
Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.
|Neostigmine methyl sulfate
Neostigmine methyl sulfate is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier.
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