Free shipping on all orders over $ 500

Adapalene

Cat. No. M2241
Adapalene Structure
Synonym:

Differin

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 55  USD55 In stock
50mg USD 60  USD60 In stock
100mg USD 92  USD92 In stock
200mg USD 135  USD135 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Adapalene is a third-generation topical retinoid, it is a potent RAR agonist, with AC50 values of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene inhibits the viability of ES-2, HOV-7, MCF-7 , Hela, SW1990, HT1080, and MM-468 cells, with IC50s of 10.36 μM, 10.81 μM, 12.00 μM, 19.08 μM, 19.52 μM, 21.70 μM, and 31.47 μM, respectively Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. 

In vivo, Adapalene (15-100 mg/kg; p.o. daily for 21 days) inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice.

Product Citations
Chemical Information
Molecular Weight 412.52
Formula C28H28O3
CAS Number 106685-40-9
Solubility (25°C) DMSO 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Aura Rusu, et al. Recent Advances Regarding the Therapeutic Potential of Adapalene

[2] No authors listed. Adapalene

[3] Brigitte Drno, et al. Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison

[4] Leila Tolaymat, et al. Adapalene

[5] S Jain. Topical tretinoin or adapalene in acne vulgaris: an overview

Related RAR/RXR Products
MSU-42011

MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist that potently inhibits the expression of iNOS as well as p-ERK protein levels. In addition, MSU-42011 has immunomodulatory and antitumor activities for cancer research.

KCL-286

KCL-286 is an orally active retinoic acid receptor-beta (RAR-beta) agonist for studies related to spinal cord injury.

XS-060

XS-060 is a potent anticancer agent and RXRα antagonist.

BPA-B9

BPA-B9 is a RXRα ligand and antagonist targeting the pRXRα-PLK1 interaction.

ER 50891 quarterhydrate

ER 50891 quarterhydrate is a potent antagonist of retinoic acid receptor α(RARα).

  Catalog
Abmole Inhibitor Catalog




Keywords: Adapalene, Differin supplier, RAR/RXR, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.