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Aclacinomycin A

Cat. No. M2141

Aclacinomycin A Structure

Synonym: Aclarubicin

Size Price Availability Quantity
10mg USD 100 In stock
50mg USD 280 In stock
200mg USD 650 In stock
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Quality Control
  • Current batch:
  • Purity >95%
  • COA
  • MSDS
Biological Activity

Aclacinomycin A (aclarubicin) is an anthracycline anticancer agent with demonstrated activity against both leukemias and solid tumors. Aclacinomycin A is the first described non-peptidic inhibitor showing discrete selectivity for the chymotrypsin-like activity of the 20 S proteasome. Aclacinomycin A significantly decreases hydrolysis of Z-E(OtBu)AL-pNA by MPC or by chymotrypsin with IC50 of 18 μM and 24 μM, respectively. Aclacinomycin A (1 μM), in combination with doxorubicin, increases cytotoxic activity of doxorubicin against K562 resistant cells. Aclacinomycin A (1 μM) partly blocks the doxorubicin efflux in resistant cell nuclei of K562 tumour cells, resulting in enhanced accumulation of doxorubicin.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 811.87
Formula C42H53NO15
CAS Number 57576-44-0
Purity >95%
Solubility DMSO 25 mg/mL
Storage at -20°C

Aclacinomycin A stabilizes topoisomerase I covalent complexes.
Nitiss JL, et al. Cancer Res. 1997 Oct 15;57(20):4564-9. PMID: 9377570.

The antitumor drug aclacinomycin A, which inhibits the degradation of ubiquitinated proteins, shows selectivity for the chymotrypsin-like activity of the bovine pituitary 20 S proteasome.
Figueiredo-Pereira ME, et al. J Biol Chem. 1996 Jul 12;271(28):16455-9. PMID: 8663210.

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Abmole Inhibitor Catalog 2017

Keywords: Aclacinomycin A, Aclarubicin supplier, Proteasome, inhibitors

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