The chemical compound acetylcholine (ACh) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs). Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro. Acetylcholine is one of many neurotransmitters in the autonomic nervous system (ANS) and the only neurotransmitter used in the motor division of the somatic nervous system.
Molecular Weight | 181.66 |
Formula | C7H16NO2.Cl |
CAS Number | 60-31-1 |
Solubility (25°C) | Water 90 mg/mL DMSO 30 mg/mL |
Storage | 2-8°C, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Daria Czuryszkiewicz, et al. Herbicidal Ionic Liquids Containing the Acetylcholine Cation
[2] Zhou-Yi Lai, et al. Role of acetylcholine in gelsenicine-induced death in mice
[5] W H Cliff, et al. Acetylcholine-activated chloride current in the T-84 colonic cell line
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α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. |
COG 133 TFA
COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. |
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α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). |
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G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors. |
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