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Acetylcholine Chloride

Cat. No. M3317
Acetylcholine Chloride Structure
Synonym:

Ach; ACh chloride

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 30  USD30 In stock
500mg USD 50  USD50 In stock
1g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

The chemical compound acetylcholine (ACh) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs). Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro. Acetylcholine is one of many neurotransmitters in the autonomic nervous system (ANS) and the only neurotransmitter used in the motor division of the somatic nervous system.

Chemical Information
Molecular Weight 181.66
Formula C7H16NO2.Cl
CAS Number 60-31-1
Solubility (25°C) Water 90 mg/mL
DMSO 30 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Daria Czuryszkiewicz, et al. Herbicidal Ionic Liquids Containing the Acetylcholine Cation

[2] Zhou-Yi Lai, et al. Role of acetylcholine in gelsenicine-induced death in mice

[3] Fabien Sauvet, et al. Acetylcholine chloride as a potential source of variability in the study of cutaneous vascular function in man

[4] A Sener, et al. Acetylcholine chloride and renal hemodynamics during postnatal maturation in conscious lambs

[5] W H Cliff, et al. Acetylcholine-activated chloride current in the T-84 colonic cell line

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Keywords: Acetylcholine Chloride, Ach; ACh chloride supplier, AChR/AChE, inhibitors, activators


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