Acecainide HCl, also known as N-acetylprocainamide and ASL 601, is the N-acetylated metabolite of procainamide. Acecainide is also a Class III antiarrhythmic agent. It can be given either intravenously or orally, and is eliminated primarily by renal excretion.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Acecainide pharmacokinetics in normal subjects of known acetylator phenotype.
Coyle JD, et al. Biopharm Drug Dispos. 1991 Nov;12(8):599-612. PMID: 1724922.
Acecainide (N-acetylprocainamide). A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cardiac arrhythmias.
Harron DW, et al. Drugs. 1990 May;39(5):720-40. PMID: 1693889.
Triton x-100 is a nonionic, non-denaturing detergent suitable for solubilization, isolation and purification of membrane protein complexes.It is chemically indistinguishable from Nonidet P-40.
Adjudin (also known as AF-2364) is a potent Cl- channel blocker, with a superior mitochondria-inhibitory effect.
2-Phenylethyl isothiocyanate is an NNK-induced lung tumorigenesis inhibitor.
Benzyl isothiocyanate is a naturally-occurring constituent of cruciferous vegetables with antibacterial properties.
Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography.
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