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Acecainide HCl

Cat. No. M8907
Acecainide HCl Structure
Synonym:

ASL 601

Size Price Availability
10mg USD 250 1-2 Weeks
50mg USD 550 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Acecainide HCl, also known as N-acetylprocainamide and ASL 601, is the N-acetylated metabolite of procainamide. Acecainide is also a Class III antiarrhythmic agent. It can be given either intravenously or orally, and is eliminated primarily by renal excretion.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 313.82
Formula C15H24ClN3O2
CAS Number 34118-92-8
Purity >98%
Solubility DMSO
Storage at -20°C
References

Acecainide pharmacokinetics in normal subjects of known acetylator phenotype.
Coyle JD, et al. Biopharm Drug Dispos. 1991 Nov;12(8):599-612. PMID: 1724922.

Acecainide (N-acetylprocainamide). A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cardiac arrhythmias.
Harron DW, et al. Drugs. 1990 May;39(5):720-40. PMID: 1693889.

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Keywords: Acecainide HCl, ASL 601 supplier, inhibitors

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