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Acebutolol hydrochloride

Cat. No. M2365
Acebutolol hydrochloride Structure
Size Price Availability Quantity
50mg USD 40  USD40 In stock
100mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.

Chemical Information
Molecular Weight 372.89
Formula C18H28N2O4.HCl
CAS Number 34381-68-5
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] A F el Walily. Analysis of nifedipine-acebutolol hydrochloride binary combination in tablets using UV-derivative spectroscopy, capillary gas chromatography and high performance liquid chromatography

[2] No authors listed. Med Lett Drugs Ther. Acebutolol

[3] B N Singh, et al. Acebutolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects

[4] G De Bono, et al. Acebutolol: ten years of experience

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