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Abametapir

Cat. No. M4463
Abametapir Structure
Synonym:

HA-44; BRN 0123183; 5,5′-Dimethyl-2,2′-dipyridyl

Size Price Availability Quantity
25mg USD 20  USD20 In stock
50mg USD 30  USD30 In stock
100mg USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Abametapir (HA-44, BRN 0123183) is an inhibitor of metalloproteinases critical for louse survival and egg development.

Chemical Information
Molecular Weight 184.24
Formula C12H12N2
CAS Number 1762-34-1
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Vernon Morrison Bowles, et al. Glob Pediatr Health. Effect of a New Head Lice Treatment, Abametapir Lotion, 0.74%, on Louse Eggs: A Randomized, Double-Blind Study

[2] Vernon M Bowles, et al. Pediatr Dermatol. Clinical studies evaluating abametapir lotion, 0.74%, for the treatment of head louse infestation

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  Catalog
Abmole Inhibitor Catalog




Keywords: Abametapir, HA-44; BRN 0123183; 5,5′-Dimethyl-2,2′-dipyridyl supplier, MMP, inhibitors, activators


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