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Abaloparatide acetate

Cat. No. M10104
Abaloparatide acetate Structure
Synonym:

BA 058 acetate; BIM 44058 acetate

Size Price Availability Quantity
1mg USD 100  USD100 In stock
5mg USD 160  USD160 In stock
10mg USD 250  USD250 In stock
25mg USD 500  USD500 In stock
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Quality Control & Documentation
Biological Activity

Abaloparatide acetate is a synthetic peptide that is related to hPTHrP and has demonstrated in preclinical testing the potential to widen the anabolic window for bone therapeutics, stimulating bone formation with a limited effect on bone resorption and mineral mobilization.

Chemical Information
Molecular Weight 4020.62
Formula C176H304N56O51
CAS Number 247062-33-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mikkel Bo Brent. Eur J Pharmacol. Abaloparatide: A review of preclinical and clinical studies

[2] Benjamin Z Leder, et al. J Clin Endocrinol Metab. Effect of Abaloparatide vs Alendronate on Fracture Risk Reduction in Postmenopausal Women With Osteoporosis

[3] Allyson Sleeman, et al. Am J Health Syst Pharm. Abaloparatide: A new pharmacological option for osteoporosis

[4] Stefano Gonnelli, et al. Clin Cases Miner Bone Metab. Abaloparatide

[5] Paul D Miller, et al. JAMA. Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial

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Keywords: Abaloparatide acetate, BA 058 acetate; BIM 44058 acetate supplier, Peptides, inhibitors, activators


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